Work

Tissue factor antigen in senile plaques of Alzheimer's disease.

Year: 1991

Type: article

Abstract: Tissue factor (tissue thromboplastin) is the primary initiator of the extrinsic coagulation pathway, triggering a proteolytic cascade when exposed to circulating coagulation factors. In this study, the distribution of tissue factor was examined immunohistochemically in Alzheimer's disease (AD) and control brains. Tissue factor was expressed diffusely in the neocortex, but in AD there was enhanced immunoreactivity in senile plaques. Although tissue factor might potentially contribute to the formation of senile plaques, it could also accumulate in the plaques as a secondary response to other biochemical perturbations.

Source: PubMed

Authors: R D McComb, K A Miller, S D Carson

Institution: University of Nebraska Medical Center

Language: English

Topic: Alzheimer's disease research and treatments

Subfield: Cellular and Molecular Neuroscience

Field: Neuroscience

Domain: Life Sciences

SDG: Good health and well-being

Open Access status: green

Funders: National Heart, Lung, and Blood Institute, National Cancer Institute

Awards: PERICELLULAR MATRIX OF HUMAN BRAIN TUMORS, CONTROL OF TISSUE FACTOR ACTIVITY