Work

Bifunctional role of glycosphingolipids. Modulators for transmembrane signaling and mediators for cellular interactions.

Year: 1990

Type: article

Abstract: Glycosphingolipids (GSLs), or their modified catabolites, at the cell surface modulate transmembrane signal transduction by influencing protein kinases associated with growth factor receptors and protein kinase C. On the other hand, the same or different GSLs at the cell surface interact in highly specific fashion with other GSLs or with binding proteins, possibly at the surface of adjacent interacting cells or in the extracellular matrix. The GSL-GSL interaction apparently provides the basis for a specific cell recognition system independent of the fibronectin/integrin or surface lectin systems, occurring earlier during a cell recognition event.

Source: Journal of Biological Chemistry

DOI: 10.1016/s0021-9258(17)30565-3

Author: S Hakomori

Language: English

Topic: Sphingolipid Metabolism and Signaling

Subfield: Molecular Biology

Field: Biochemistry, Genetics and Molecular Biology

Domain: Life Sciences

Open Access status: hybrid

Estimated APC paid: $3,430

Funder: National Cancer Institute

Award: GLYCOLIPIDS--CELL INTERACTION/PROLIFERATION/ONCOGENESIS