Year: 1989
Type: article
Abstract: Liver transplantation is a therapeutic option for a number of liver diseases.1 While the kinetics of several drugs are known to be altered in liver disease, very little is known about drug kinetics in liver transplant patients. Since liver transplant patients receive multiple drugs, a thorough understanding of the kinetics of these agents is essential for optimization of drug therapy in this patient population.
Previous studies from our laboratory have shown the oxidative drug-metabolizing capacity of the transplanted liver in clinically stable liver transplant patients to be similar to that of the normal liver.2 The objective of the present study was to characterize the conjugative drug metabolism of the liver in clinically stable liver transplant patients using acetaminophen (APA) as a model drug.
Source: PubMed
Authors: R Venkataramanan, K Kalp, M Rabinovitch, R Cuellar, R J Ptachcinski, L Teperman, L Makowka, G J Burckart, D H Van Thiel, T E Starzl
Institution: University of Pittsburgh
Language: English
Subfield: Pharmacology
Domain: Life Sciences
Open Access status: green
OpenAlex ID: W168388739