Work

Regulatory T cells and Foxp3

Year: 2011

Type: review

Abstract: Regulatory T (Treg) cells play central role in regulation of immune responses to self-antigens, allergens, and commensal microbiota as well as immune responses to infectious agents and tumors. Transcriptional factor Foxp3 serves as a lineage specification factor of Treg cells. Paucity of Treg cells due to loss-of-function mutations of the Foxp3 gene is responsible for highly aggressive, fatal, systemic immune-mediated inflammatory lesions in mice and humans. Recent studies of Foxp3 expression and function provided critical novel insights into biology of Treg cells and into cellular mechanisms of the immune homeostasis.

Source: Immunological Reviews

DOI: 10.1111/j.1600-065x.2011.01018.x

Author: Alexander Y. Rudensky

Institutions: Memorial Sloan Kettering Cancer Center, Howard Hughes Medical Institute

Language: English

Topic: T-cell and B-cell Immunology

Subfield: Immunology

Field: Immunology and Microbiology

Domain: Life Sciences

SDG: Good health and well-being

Open Access status: green

Funders: Howard Hughes Medical Institute, National Institute of Allergy and Infectious Diseases