Work

Translational genomics in cancer research: converting profiles into personalized cancer medicine.

Year: 2013

Type: article

Abstract: Cancer genomics is a rapidly growing discipline in which the genetic molecular basis of malignancy is studied at the scale of whole genomes. While the discipline has been successful with respect to identifying specific oncogenes and tumor suppressors involved in oncogenesis, it is also challenging our approach to managing patients suffering from this deadly disease. Specifically cancer genomics is driving clinical oncology to take a more molecular approach to diagnosis, prognostication, and treatment selection. We review here recent work undertaken in cancer genomics with an emphasis on translation of genomic findings. Finally, we discuss scientific challenges and research opportunities emerging from findings derived through analysis of tumors with high-depth sequencing.

Source: PubMed

DOI: 10.7497/j.issn.2095-3941.2013.04.005

Authors: Lalit Patel, Brittany Parker, Da Yang, Wei Zhang

Institutions: The University of Texas MD Anderson Cancer Center, The University of Texas Health Science Center at Houston

Language: English

Topic: Cancer Genomics and Diagnostics

Subfield: Cancer Research

Field: Biochemistry, Genetics and Molecular Biology

Domain: Life Sciences

SDG: Good health and well-being

Open Access status: green

Funders: National Institutes of Health, University of Texas MD Anderson Cancer Center, National Cancer Institute