Antiphospholipid Antibodies In Patients With Venous Thrombosis At Kenyatta National Hospital
Year: 2013
Type: article
Study design: Observational Study
Abstract: Objective: To determine the presence and types of antiphospholipid antibodies in patients with venous thrombosis at Kenyatta National Hospital. Design: A cross-sectional descriptive study. Setting: This study was conducted at Kenyatta National Hospital (KNH), a major referral and teaching hospital in Nairobi, Kenya, between January and November 2011. The study areas included the Accident and Emergency department, wards and outpatient clinics, and the Haematology and Immunology laboratories. Participants: Male and female adult patients diagnosed with venous thrombosis confirmed by Doppler ultrasound or MRI. Main outcome measures: Age, gender, presence or absence of lupus anticoagulant, and titres of anticardiolipin (ACL) and anti-2-GP1 antibodies (anti-2GP1). Materials and Methods: Demographic and clinical information was collected by direct interview of patients. Every patient was examined for clinical manifestations of APA and blood drawn for laboratory tests. A proforma questionnaire was used to collect all the information. The data collected was pooled, screened and entered into SPSS v.19 software for analysis. Results: A total of 60 patients were studied. Majority of the patients, 52 (86.7%), were females, while males were 8 (13.3%). The mean age was 38.3 years (± 13.7), with a median (IQR) of 52 years (38.8, 58) for males vs. 32.5 years (24.8, 43.5) for females, p value 0.16; positive for LA), and all 20 (100%) who had a prolonged APTT had a negative DRVVT (NR
Source: African journal of rheumatology
Author: Gonti er Cs
Language: English
Subfield: Rheumatology
Field: Medicine
Domain: Health Sciences
Open Access status: diamond
OpenAlex ID: W169699332