Year: 2013
Type: article
Study design: Observational Study
Abstract: There is growing evidence of the protective role of the Mediterranean diet (MD) on cancer. However, to date no epidemiological study has investigated the influence of the MD on bladder cancer. We evaluated the association between adherence to the MD and risk of urothelial cell bladder cancer (UCC), according to tumor aggressiveness, in the European Prospective Investigation into Cancer and Nutrition (EPIC). The analysis included 477,312 participants, recruited from ten European countries between 1991 and 2000. Information from validated dietary questionnaires was used to develop a relative Mediterranean diet score (rMED), including nine dietary components. Cox regression models were used to assess the effect of the rMED on UCC risk, while adjusting for dietary energy and tobacco smoking of any kind. Stratified analyses were performed by sex, BMI, smoking status, European region and age at diagnosis. During an average follow-up of 11 years, 1,425 participants (70.9% male) were diagnosed with a first primary UCC. There was a negative but non-significant association between a high versus low rMED score and risk of UCC overall (HR: 0.84 [95% CI 0.69, 1.03]) and risk of aggressive (HR: 0.88 [95% CI 0.61, 1.28]) and non-aggressive tumors (HR: 0.78 [95% CI 0.54, 1.14]). Although there was no effect modification in the stratified analyses, there was a significant 34% (p = 0.043) decreased risk of UCC in current smokers with a high rMED score. In EPIC, the MD was not significantly associated with risk of UCC, although we cannot exclude that a MD may reduce risk in current smokers.
Source: International Journal of Cancer
DOI: 10.1002/ijc.28573
Authors: G. Buckland, M.M. Ros, N. Roswall, H.B. Bueno-de-Mesquita, N. Travier, A. Tjonneland, L.A. Kiemeney, C. Sacerdote, R. Tumino, B. Ljungberg, I.T. Gram, E. Weiderpass, G. Skeie, J. Malm, R. Ehrnström, J. Chang-Claude, A. Mattiello, C. Agnoli, P.H. Peeters, M.C. Boutron-Ruault, G. Fagherazzi, F. Clavel-Chapelon, L.M. Nilsson, P. Amiano, A. Trichopoulou, E. Oikonomou, K. Tsiotas, M.J. Sánchez, K. Overvad, J.R. Quirós, M.D Chirlaque, A. Barricarte, T.J. Key, N.E. Allen, K.T. Khaw, N. Wareham, E. Riboli, R. Kaaks, H. Boeing, D. Palli, I. Romieu, D. Romaguera, C.A. Gonzalez
Institutions: Institut d'Investigació Biomédica de Bellvitge, Institut Català d'Oncologia, National Institute for Public Health and the Environment, Danish Cancer Society, University Medical Center Utrecht, Imperial College London, Radboud University Medical Center, Italian institute for Genomic Medicine, Piedmont Reference Center for Epidemiology and Cancer Prevention, Umeå University, University of Hawaii Cancer Center, UiT The Arctic University of Norway, Karolinska Institutet, Cancer Registry of Norway, Folkhälsans Forskningscentrum, Lund University, Skåne University Hospital, Region Skåne, German Cancer Research Center, Federico II University Hospital, University of Naples Federico II, Fondazione IRCCS Istituto Nazionale dei Tumori, Inserm, Centre de recherche en Epidémiologie et Santé des Populations, Biogipuzkoa Health Research Institute, Centro de Investigación Biomédica en Red de Epidemiología y Salud Pública, National and Kapodistrian University of Athens, Hellenic Health Foundation, Andalusian School of Public Health, Aarhus University, Gobierno del Principado de Asturias, Instituto de Salud Pública de Navarra, Gobierno de Navarra, University of Oxford, University of Cambridge, MRC Epidemiology Unit, German Institute of Human Nutrition, Istituto per lo Studio e la Prevenzione Oncologica, Centre international de recherche sur le cancer, Centro de Investigación Biomédica en Red
Language: English
Topic: Nutritional Studies and Diet
Field: Medicine
Domain: Health Sciences
Open Access status: hybrid
Estimated APC paid: $5,030
Funders: Cancer Research UK, National Institute for Health and Care Research, European Commission, Bundesministerium für Bildung und Forschung, Cancerfonden, NordForsk, Norges Forskningsråd, Deutsche Krebshilfe, Hellenic Health Foundation, Medical Research Council, World Cancer Research Fund, Instituto de Salud Carlos III
OpenAlex ID: W1697685601