Work

Inhibition of Rab5 Activation During Insulin Receptor-Mediated Endocytosis.

Year: 2011

Type: article

Abstract: inhibitor affected the association of Rin1 to membrane upon insulin stimulation. Furthermore, Rin1 did not fully support endosome fusion in the presence of the AG1024 inhibitor. These results constitute the first evidence that, at least in part, the enzymatic activity of insulin receptor is required for the fusion events via the activation of Rab5.

Source: PubMed

Authors: Ivan Jozic, Gustavo Blanco, M Alejandro Barbieri

Institutions: Florida International University, University of Kansas Medical Center

Language: English

Topic: Cellular transport and secretion

Subfield: Cell Biology

Field: Biochemistry, Genetics and Molecular Biology

Domain: Life Sciences

SDG: Good health and well-being

Open Access status: green

Funder: National Institute of Diabetes and Digestive and Kidney Diseases

Award: Intracellular Receptor Trafficking