Work

Inhalable Curcumin: Offering the Potential for Translation to Imaging and Treatment of Alzheimer's Disease

Year: 2015

Type: article

Abstract: Curcumin is a promising compound that can be used as a theranostic agent to aid research in Alzheimer's disease. Beyond its ability to bind to amyloid plaques, the compound can also cross the blood-brain barrier. Presently, curcumin can be applied only to animal models, as the formulation needed for iv injection renders it unfit for human use. Here, we describe a novel technique to aerosolize a curcumin derivative, FMeC1, and facilitate its safe delivery to the brain. Aside from the translational applicability of this approach, a study in the 5XFAD mouse model suggested that inhalation exposure to an aerosolized FMeC1 modestly improved the distribution of the compound in the brain. Additionally, immunohistochemistry data confirms that following aerosol delivery, FMeC1 binds amyloid plaques expressed in the hippocampal areas and cortex.

Source: Journal of Alzheimer s Disease

DOI: 10.3233/jad-140798

Authors: Richard McClure, Daijiro Yanagisawa, Donald Stec, Dave Abdollahian, Dmitry Koktysh, Dritan Xhillari, Rudolph Jaeger, Gregg Stanwood, Eduard Chekmenev, Ikuo Tooyama, John C. Gore, Wellington Pham

Institutions: Vanderbilt University, Shiga University of Medical Science, Vanderbilt-Ingram Cancer Center

Language: English

Topic: Alzheimer's disease research and treatments

Subfield: Physiology

Field: Medicine

Domain: Health Sciences

SDG: Good health and well-being

Open Access status: green

Funders: National Institutes of Health, Japan Society for the Promotion of Science, National Cancer Institute, National Institute of General Medical Sciences, National Institute of Biomedical Imaging and Bioengineering, Eunice Kennedy Shriver National Institute of Child Health and Human Development

Awards: G1773116938, G3403902456, Development of novel diagnostic and therapeutic methods on Alzheimer's disease by targeting amyloid oligomers, Medical Scientist Training Program, LSM880-Airyscan Confocal Microscope for Large Shared Resource, Eunice Kennedy Shriver Intellectual and Developmental Disabilities Research Center at Vanderbilt University, Multifunctional Nanoparticles for Image-Guided Vaccine Delivery in Cancer, Institutional Predoctoral Training Program in Biomedical Imaging Science, Study of a highly sensitive C-13 MR glucose metobolite mapping with the brain of an Altzheimer model mouse

OpenAlex ID: W1699897968

FWCI: 5.795

Cites: 41

Cited by: 47

Related to: 10