Therapeutic Potential of siRNA-mediated Targeting of Urokinase Plasminogen Activator, Its Receptor, and Matrix Metalloproteinases
Year: 2008
Type: book-chapter
Abstract: Targeting proteases and their activators would retard the invasive ability of cancer cells, and has been shown to induce apoptosis in certain instances. Various methods have been developed to specifically target protease molecules in an attempt to retard invasion and migration. Of these methods, RNA interference (RNAi) holds great therapeutic potential. RNAi technology is now being used to target specific molecules for use as potential anti-cancer agents. RNAi-mediated silencing is almost catalytic when compared to anti-sense silencing. Of these targets, the uPAR-uPA system and MMPs holds great promise. Targeting uPA/uPAR may provide additive or synergistic treatment benefits if used in combination with conventional therapeutics such as chemotherapy or radiation. Studies point to the fact that specifically targeting MMP-9 or MMP-2 singly or in combination with other proteases could have specific therapeutic implications in the treatment of cancer. In this chapter we discuss the therapeutic potential of siRNA-mediated targeting of the uPAR-uPA system and MMPs as therapeutic agents for the treatment of cancer.
Source: Methods in molecular biology
Authors: Christopher S. Gondi, Jasti S. Rao
Institution: Peoria campus of the University of Illinois System
Language: English
Subfield: Cancer Research
Domain: Life Sciences
Open Access status: green
Awards: Regression of meningioma tumor growth by combination therapy, Suppression of glioma invasion by a bicistronic constuct, Role of TFPI-2 in human gliomas invasiveness, Role of uPA and uPAR in Human Glioma Invasiveness, Growth inhibition of brain tumors by cord blood stem cells, Inhibition of glioma tumor growth by antisense MMP-9, Cath B and uPAR si RNA constructs regressed glioma growth
OpenAlex ID: W1705608888