High Excitability and Remained Slow Calcium Repolarization Components of Action Potentials in Cultured Human Paramyotonia Congenita Muscle Cells
Year: 1990
Type: article
Abstract: Electrophysiological parameters of cultured muscle cells of two patients with paramyotonia congenita (PC) (son: age 10, moderately affected; father: age 43, mildly affected) were compared with cultures of eight control patients.In PC patients, repetitive discharges after electrical stimulations were present in 100% of the son's cells and 91% of the father's cells but in only 4.3% of control cells.Mean resting membrane potentials (RMPs) were 63 i 2 mV in the son's cells, 59 i 1 mV in the
Source: Biomedical Research
Authors: TAKAYOSHI KOBAYASHI, VALERIE ASKANAS, WILLIAM KING ENGEL
Institution: University of Southern California
Language: English
Subfield: Molecular Biology
Domain: Life Sciences
Open Access status: bronze
OpenAlex ID: W1706787181