Work

Protumor effects of proinflammatory mediators in breast cancer

Year: 2012

Type: article

Abstract: Inflammation is defined as an enabling characteristic of malignant growth.Many proinflammatory mediators have protumor capabilities.In this review we focus on the protumor effect of cytokines and chemokines in breast cancer.We discuss the role of interleukin 1b, interleukin 6, tumor necrosis factor a, CCL2, CCL5, and CXCL12 and its receptor CXCR4 as typical mediators implicated in breast cancer progression.We also analyze the impact of transcription factor NF-kB. Proinflammatory mediators with protumor effects should be considered as therapeutic targets in breast cancer.It is challenging how to find optimal anti-cytokine and anti-chemokine regiments as a part of anticancer therapy.

Source: Hrčak Portal of scientific journals of Croatia (University Computing Centre)

Authors: Maja Sirotković-Skerlev, Ana Kulić, Lada Bradić, Tamara Čačev

Institutions: University Hospital Centre Zagreb, University of Zagreb, Ruđer Bošković Institute

Language: English

Topic: Chemokine receptors and signaling

Subfield: Oncology

Field: Medicine

Domain: Health Sciences

SDG: Good health and well-being

Open Access status: green

OpenAlex ID: W170845523

FWCI:

Cites: 92

Cited by: 4

Related to: 10