Caveolae and Cancer, The controversial role of caveolin-1
Year: 2010
Type: dissertation
Abstract: More than fifty years ago caveolae were discovered and marked as a new endocytic\nmechanism. Later it was found that they are formed in microdomains of the plasma\nmembrane, called lipid rafts. The caveolar endocytotic route is known to transport several\nmolecules like, membrane components and growth receptors into the cell. The main\nfunctional components of caveolae are the caveolins, caveolin-1, caveolin-2 and caveolin-3.\nThese proteins are not only necessary for caveolae formation and dynamics, but are also\ninvolved in the regulation of several signaling molecules. Caveolae may play a role in\ntumorigenesis. In this thesis we aim to discuss the recent progress in our understanding of\nthe role of caveolins in cancer. Caveolin-1 is known to act as both, a tumor suppressor and\nan onco-protein, here we will explain how this difference is established.
Author: Judith H.I. Haarhuis
Language: English
Subfield: Cell Biology
Domain: Life Sciences
Open Access status: green
OpenAlex ID: W171020692