Formylpeptide receptor 1 mediates the tumorigenicity of human hepatocellular carcinoma cells
Year: 2015
Type: article
Abstract: G protein-coupled chemoattractant receptors (GPCRs) have been implicated in cancer progression. Formylpeptide receptor 1 (FPR1) was originally identified as a GPCR mediating anti-microbial host defense. However, the role of FPR1 in tumorigenesis remains poorly understood. The current study aims to investigate the potential of FPR1 to regulate human hepatoma growth and invasion. We found the FPR1 gene and protein expression in human intratumoral and peritumoral tissues of hepatocellular carcinoma (HCC) specimens and in human hepatoma cell lines. FPR1 activation mediated the migration, calcium mobilization and ERK-dependent IL-8 production by hepatic cancer cells. FPR1 knockdown substantially reduced the tumorigenicity of hepatoma cells in nude mice. Necrotic hepatic tumor cells released factor(s) that activated FPR1 in live tumor cells. Our results indicate a critical role of FPR1 in the progression of malignant human hepatic cancer. FPR1 thus may represent a molecular target for the development of novel anti-hepatoma therapeutics.
Source: OncoImmunology
Authors: Liang Zhang, Huanyu Wang, Tianshu Yang, Zhifeng Su, Dan Fang, Yafeng Wang, Jiazhu Fang, Xinwei Hou, Yingying Le, Keqiang Chen, Ji Ming Wang, Shao Bo Su, Qing Lin, Qi Zhou
Institutions: Sun Yat-sen University Cancer Center, State Key Laboratory of Oncology in South China, Sun Yat-sen University, The First Affiliated Hospital, Sun Yat-sen University, Tongji University, Shanghai Tenth People's Hospital, South China University of Technology, Chinese Academy of Sciences, Shanghai Institutes for Biological Sciences, Frederick National Laboratory for Cancer Research, National Cancer Institute, Johns Hopkins University, Johns Hopkins Medicine, Johns Hopkins Hospital
Language: English
Subfield: Oncology
Field: Medicine
Domain: Health Sciences
Open Access status: gold
Estimated APC paid: $2,913
OpenAlex ID: W1712302576