Small molecules from the human microbiota
Year: 2015
Type: review
Abstract: Developments in the use of genomics to guide natural product discovery and a recent emphasis on understanding the molecular mechanisms of microbiota-host interactions have converged on the discovery of small molecules from the human microbiome. Here, we review what is known about small molecules produced by the human microbiota. Numerous molecules representing each of the major metabolite classes have been found that have a variety of biological activities, including immune modulation and antibiosis. We discuss technologies that will affect how microbiota-derived molecules are discovered in the future and consider the challenges inherent in finding specific molecules that are critical for driving microbe-host and microbe-microbe interactions and understanding their biological relevance.
Source: Science
Authors: Mohamed S. Donia, Michael A. Fischbach
Institutions: Princeton University, QB3, University of California, San Francisco
Language: English
Subfield: Applied Microbiology and Biotechnology
Field: Immunology and Microbiology
Domain: Life Sciences
Open Access status: green
Funders: David and Lucile Packard Foundation, Burroughs Wellcome Fund, W. M. Keck Foundation, Princeton University, National Institutes of Health, Defense Advanced Research Projects Agency, National Institute of General Medical Sciences, National Institute of Allergy and Infectious Diseases, National Institute of Diabetes and Digestive and Kidney Diseases
Awards: Identifying and characterizing small molecules from the human microbiome, G2084096158, Exploring Design Principles of Cellular Control Circuits, Antibiotics from nose and throat commensals that impact pathogen colonization, Dietary and Microbial Reprogramming of Intestinal Microbiota-Produced Metabolites
OpenAlex ID: W1715339469