The Role of Nrf2 in the Differential Susceptibility of Male and Female Mice to Acetaminophen-Induced Hepatotoxicity
Year: 2014
Type: dissertation
Abstract: mice.Furthermore, a significantly greater induction of Nqo1 and multidrug resistance-associated protein 4 (Mrp4) mRNA expression was observed in both naïve and overnight-fasted WT and Nrf2null female than male livers following APAP administration, resulting in significantly greater mRNA expression of these genes in female than male livers.ALT activity was also significantly elevated in both overnight-fasted WT and Nrf2-null male mice following APAP administration, but no increases in ALT were observed in either genotype of female mice.These results indicate that other factors, rather than Nrf2, are responsible for the lower susceptibility of female mice to APAP hepatotoxicity.
Author: Philip Rohrer
Language: English
Subfield: Pharmacology
Domain: Life Sciences
Open Access status: green
OpenAlex ID: W171918836