Year: 2009
Type: dissertation
Abstract: Section I 2 A decade of genome-wide gene expression profiling in acute myeloid leukemia: flashback and prospects 3 Prediction of molecular subtypes in acute myeloid leukemia based on gene expression profiling Section II 4 Tribbles homolog 2 inactivates C/EBPα and causes acute myelogenous leukemia 5 Distinct gene expression profiles of acute myeloid/T-lymphoid leukemia with silenced CEBPA and mutations in NOTCH1 6 Genome wide epigenetic analysis delineates a biologically distinct immature acute leukemia with myeloid/T-lymphoid features Section III 7 A recurrent in-frame insertion in a CEBPA transactivation domain is a polymorphism rather than a mutation that does not affect gene expression profiling-based clustering of AML 8 Segmental uniparental disomy as a recurrent mechanism for homozygous CEBPA mutations in acute myeloid leukemia 9 Double CEBPA mutations, but not single CEBPA mutations, define a subgroup of acute myeloid leukemia with a distinctive gene expression profile that is uniquely associated with a favorable outcome Section IV 10 CCAAT/enhancer binding protein alpha target genes in myeloid progenitor cells uncovered by chromatin immunoprecipitation on DNA promoter microarrays (ChIP-chip) 11 Summary and general discussion
Author: Bas J. Wouters
Language: English
Subfield: Hematology
Field: Medicine
Domain: Health Sciences
Open Access status: green
OpenAlex ID: W1719943219