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Splenectomy ameliorates hematologic toxicity of hyperthermic intraperitoneal chemotherapy.

Year: 2011

Type: article

Abstract: BACKGROUND: Cytoreductive surgery and hyperthermic intraperitoneal chemotherapy is a promising modality for peritoneal carcinomatosis. Splenectomy is frequently required, however effect upon hematotoxicity is unknown. METHODS: 195 patients undergoing the procedure were evaluated and granulocyte colony stimulating factor administered for white blood cell counts <4.0. RESULTS: 52% of 195 underwent splenectomy; average white blood cell and platelet nadirs were 6.1,172. Non-splenectomy patients averaged white blood cell nadir 4.6, platelet nadir 164.1. Granulocyte colony stimulating factor administered in 29% of splenectomy, 43% of non-splenectomy (P=0.043). CONCLUSION: Splenectomy ameliorates hematotoxicity of hyperthermic intraperitoneal chemotherapy and significantly reduces post-operative granulocyte colony stimulating factor requirements.

Source: PubMed Central

DOI: 10.3978/j.issn.2078-6891.2011.011

Authors: Robert D Becher, Perry Shen, John H Stewart, Greg Russell, Joel F Bradley, Edward A Levine

Institutions: Wake Forest University Health Sciences, Wake Forest University, Atrium Health Wake Forest Baptist

Language: English

Topic: Intraperitoneal and Appendiceal Malignancies

Subfield: Surgery

Field: Medicine

Domain: Health Sciences

SDG: Good health and well-being

Open Access status: green

OpenAlex ID: W1733776642

FWCI: 1.311

Cites: 26

Cited by: 19

Related to: 10