Work

The link between angiotensin II-mediated anxiety and mood disorders with NADPH oxidase-induced oxidative stress.

Year: 2012

Type: article

Abstract: The renin-angiotensin system (RAS) and its active peptide angiotensin II (AngII) have major involvements not only in hypertension but also in mood and anxiety disorders. Substantial evidence supports the notion that AngII acts as a neuromodulator in the brain. In this review, we provide an overview of the link between the RAS and anxiety or mood disorders, and focus on recent advances in the understanding of AngII-linked, NADPH oxidase-derived oxidative stress in the central nervous system, which may underlie pathogenesis of mood and anxiety disorders.

Source: Europe PMC (PubMed Central)

Authors: Feng Liu, Jennifer Havens, Qi Yu, Gang Wang, Robin L Davisson, Virginia M Pickel, Costantino Iadecola

Language: English

Topic: Renin-Angiotensin System Studies

Subfield: Cardiology and Cardiovascular Medicine

Field: Medicine

Domain: Health Sciences

SDG: Good health and well-being

Open Access status: green

Funders: National Heart, Lung, and Blood Institute, National Institute of Mental Health

Awards: Ultrastructure of Mesolimbic Transmitter Interactions, Ultrastructure of Mesolimbic Transmitter Interactions, FOREBRAIN PLASTICY IN HYPERTENSION

OpenAlex ID: W1734438656

FWCI: 2.079

Cites: 60

Cited by: 37

Related to: 10