Work

Very Early Recurrence of Anti-Phospholipase A2 Receptor-Positive Membranous Nephropathy After Transplantation

Year: 2012

Type: article

Abstract: Membranous nephropathy is a common cause of adult nephrotic syndrome, with recent evidence suggesting that 70% of idiopathic disease is associated with anti-Phospholipase A(2) receptor autoantibodies. We describe a 63-year-old man with membranous nephropathy who underwent a kidney transplant and developed recurrent membranous nephropathy with fine granular co-localization of Phospholipase A(2) receptor and IgG evident on transplant biopsy on day 6 and elevated circulating levels of serum anti-Phospholipase A(2) receptor autoantibody that declined over time in conjunction with improvement in the serum creatinine and urinary protein. This is a very early case of Phospholipase A(2) receptor-associated recurrent membranous nephropathy with circulating anti-Phospholipase A(2) receptor autoantibody, which supports the emerging evidence that idiopathic membranous nephropathy is an autoimmune disease.

Source: American Journal of Transplantation

DOI: 10.1111/j.1600-6143.2011.03957.x

Authors: C.D. Blosser, R. Ayalon, R. Nair, C. Thomas, L.H. Beck

Institutions: University of Iowa, Iowa City VA Medical Center, Boston University, Boston Medical Center

Language: English

Topic: Renal Diseases and Glomerulopathies

Subfield: Nephrology

Field: Medicine

Domain: Health Sciences

SDG: Good health and well-being

Open Access status: hybrid

Estimated APC paid: $4,300