Year: 2005
Type: dissertation
Abstract: Lymph node postive disease Parameter Reference Patients Relevant findings Nixon, 1994 17 1398 Young age (<35) predicts time to recurrence (relative risk = 1.73) and time to metastasis (relative risk = 1.70; borderline significance) Yildirim, 2000 18 135 Young age predicts decreased disease free survival (13% vs. 61%) after 5 years Age Faneyte, 2004 24 739 Young age (<40) predicts both recurrence (26% vs. 16%) and death (13% vs. 8%) within 2 years Size Quiet, 1996 25 501 Smaller tumors (≤2 cm) with limited (<4) lymph node involvement behave comparable to node negative disease (73% -81% disease free survival) Grade Clayton, 1993 26 399 In 4 years from diagnosis 75% of mortality among grade 3 tumors (with high mitotic count) had occurred versus 25% among grade 1 tumors Carter, 1989 19 11276 Overall survival decreases with increasing lymph node involvement Quiet, 1996 25 501 Disease free survival of patients with extensive (>3) lymph node involvement is poor, suggesting likely systemic disease Positive nodes Jatoi, 1999 27 1696 Extensive (>3) lymph node involvement predicts decreased survival after first recurrence compared to less (0 -4) lymph node involvement (hazard ratio = 2.5)
Author: Ian F. Faneyte
Language: English
Subfield: Cancer Research
Domain: Life Sciences
Open Access status: green
OpenAlex ID: W1737877898