The CODATwins Project: The Cohort Description of Collaborative Project of Development of Anthropometrical Measures in Twins to Study Macro-Environmental Variation in Genetic and Environmental Effects on Anthropometric Traits
Year: 2015
Type: article
Abstract: For over 100 years, the genetics of human anthropometric traits has attracted scientific interest. In particular, height and body mass index (BMI, calculated as kg/m2) have been under intensive genetic research. However, it is still largely unknown whether and how heritability estimates vary between human populations. Opportunities to address this question have increased recently because of the establishment of many new twin cohorts and the increasing accumulation of data in established twin cohorts. We started a new research project to analyze systematically (1) the variation of heritability estimates of height, BMI and their trajectories over the life course between birth cohorts, ethnicities and countries, and (2) to study the effects of birth-related factors, education and smoking on these anthropometric traits and whether these effects vary between twin cohorts. We identified 67 twin projects, including both monozygotic (MZ) and dizygotic (DZ) twins, using various sources. We asked for individual level data on height and weight including repeated measurements, birth related traits, background variables, education and smoking. By the end of 2014, 48 projects participated. Together, we have 893,458 height and weight measures (52% females) from 434,723 twin individuals, including 201,192 complete twin pairs (40% monozygotic, 40% same-sex dizygotic and 20% opposite-sex dizygotic) representing 22 countries. This project demonstrates that large-scale international twin studies are feasible and can promote the use of existing data for novel research purposes.
Source: Twin Research and Human Genetics
DOI: 10.1017/thg.2015.29
Authors: Karri Silventoinen, Aline Jelenkovic, Reijo Sund, Chika Honda, Sari Aaltonen, Yoshie Yokoyama, Adam D. Tarnoki, David L. Tarnoki, Feng Ning, Fuling Ji, Zengchang Pang, Juan R. Ordoñana, Juan F. Sánchez-Romera, Lucia Colodro-Conde, S. Alexandra Burt, Kelly L. Klump, Sarah E. Medland, Grant W. Montgomery, Christian Kandler, Tom A. McAdams, Thalia C. Eley, Alice M. Gregory, Kimberly J. Saudino, Lise Dubois, Michel Boivin, Claire M. A. Haworth, Robert Plomin, Sevgi Y. Öncel, Fazil Aliev, Maria A. Stazi, Corrado Fagnani, Cristina D’Ippolito, Jeffrey M. Craig, Richard Saffery, Sisira H. Siribaddana, Matthew Hotopf, Athula Sumathipala, Timothy Spector, Massimo Mangino, Genevieve Lachance, Margaret Gatz, David A. Butler, Gombojav Bayasgalan, Danshiitsoodol Narandalai, Duarte L. Freitas, José Antonio Maia, K. Paige Harden, Elliot M. Tucker-Drob, Kaare Christensen, Axel Skytthe, Kirsten O. Kyvik, Changhee Hong, Youngsook Chong, Catherine A. Derom, Robert F. Vlietinck, Ruth J. F. Loos, Wendy Cozen, Amie E. Hwang, Thomas M. Mack, Mingguang He, Xiaohu Ding, Billy Chang, Judy L. Silberg, Lindon J. Eaves, Hermine H. Maes, Tessa L. Cutler, John L. Hopper, Kelly Aujard, Patrik K. E. Magnusson, Nancy L. Pedersen, Anna K. Dahl Aslan, Yun-Mi Song, Sarah Yang, Kayoung Lee, Laura A. Baker, Catherine Tuvblad, Morten Bjerregaard-Andersen, Henning Beck-Nielsen, Morten Sodemann, Kauko Heikkilä, Qihua Tan, Dongfeng Zhang, Gary E. Swan, Ruth Krasnow, Kerry L. Jang, Ariel Knafo-Noam, David Mankuta, Lior Abramson, Paul Lichtenstein, Robert F. Krueger, Matt McGue, Shandell Pahlen, Per Tynelius, Glen E. Duncan, Dedra Buchwald, Robin P. Corley, Brooke M. Huibregtse, Tracy L. Nelson, Keith E. Whitfield, Carol E. Franz, William S. Kremen, Michael J. Lyons, Syuichi Ooki, Ingunn Brandt, Thomas Sevenius Nilsen, Fujio Inui, Mikio Watanabe, Meike Bartels, Toos C. E. M. van Beijsterveldt, Jane Wardle, Clare H. Llewellyn, Abigail Fisher, Esther Rebato, Nicholas G. Martin, Yoshinori Iwatani, Kazuo Hayakawa, Finn Rasmussen, Joohon Sung, Jennifer R. Harris, Gonneke Willemsen, Andreas Busjahn, Jack H. Goldberg, Dorret I. Boomsma, Yoon-Mi Hur, Thorkild I. A. Sørensen, Jaakko Kaprio
Institutions: University of Helsinki, The University of Osaka, University of the Basque Country, Osaka City University, Semmelweis University, Qingdao Municipal Center for Disease Control and Prevention, Instituto Murciano de Investigación Biosanitaria, Universidad de Murcia, QIMR Berghofer Medical Research Institute, Michigan State University, Bielefeld University, King's College London, Goldsmiths University of London, Boston University, University of Ottawa, Université Laval, University of Warwick, Kırıkkale University, Karabük University, Virginia Commonwealth University, Istituto Superiore di Sanità, Royal Children's Hospital, The University of Melbourne, Murdoch Children's Research Institute, Institute for Research and Development, Rajarata University of Sri Lanka, South London and Maudsley NHS Foundation Trust, NIHR School for Primary Care Research, Keele University, University of Southern California, National Academy of Medicine, National Academy of Sciences, Hiroshima University, Universidade da Madeira, Universidade do Porto, The University of Texas at Austin, University of Southern Denmark, Odense University Hospital, Pusan National University, Universitair Ziekenhuis Leuven, Icahn School of Medicine at Mount Sinai, USC Norris Comprehensive Cancer Center, Sun Yat-sen University, Centre for Eye Research Australia, State Key Laboratory of Ophthalmology, Zhongshan Ophthalmic Center, Sun Yat-sen University, VCU Massey Comprehensive Cancer Center, Seoul National University, Karolinska Institutet, Jönköping University, Samsung Medical Center, Sungkyunkwan University, Inje University, Inje University Busan Paik Hospital, Örebro University, Statens Serum Institut, Bandim Health Project, Qingdao University, Stanford Medicine, Stanford University, SRI International, University of British Columbia, Hebrew University of Jerusalem, Hadassah Medical Center, University of Minnesota, University of Washington, Colorado School of Public Health, Colorado State University, Duke University, University of California San Diego, VA San Diego Healthcare System, Center of Excellence for Stress and Mental Health, Ishikawa Prefectural Nursing University, Norwegian Institute of Public Health, Kio University, Vrije Universiteit Amsterdam, University College London, Mokpo National University, University of Copenhagen, Novo Nordisk Foundation, Frederiksberg Hospital, Bispebjerg Hospital, University of Bristol, MRC Integrative Epidemiology Unit, Novo Nordisk Foundation Center for Basic Metabolic Research, Finnish Institute for Health and Welfare, Institute for Molecular Medicine Finland
Language: English
Subfield: Genetics
Domain: Life Sciences
Open Access status: bronze
Funders: U.S. Department of Veterans Affairs, Tobacco-Related Disease Research Program, University of Southern California, Velux Stiftung, Michigan State University, Fundación Séneca, University of Washington, Bonnie Babes Foundation, Wellcome Trust, Center of Excellence for Stress and Mental Health, Michigan State University Foundation, Kırıkkale Üniversitesi, Cancer Research UK, National Institute for Health and Care Research, Leverhulme Trust, King's College London, European Commission, National Research Foundation, University of Melbourne, National Natural Science Foundation of China, ZonMw, Vrije Universiteit Amsterdam, Academy of Finland, Nederlandse Organisatie voor Wetenschappelijk Onderzoek, National Research Foundation of Korea, Türkiye Bilimsel ve Teknolojik Araştırma Kurumu, State Government of Victoria, Ministerio de Ciencia e Innovación, Vlaamse regering, National Institutes of Health, Directorate for Biological Sciences, College of Engineering, Michigan State University, Forsknings- og Innovationsstyrelsen, Medical Research Council, Biotechnology and Biological Sciences Research Council, Economic and Social Research Council, National Health and Medical Research Council, Japan Society for the Promotion of Science, Danish Agency for Science and Higher Education, Fundação para a Ciência e a Tecnologia, National Institute on Alcohol Abuse and Alcoholism, National Institute on Aging, National Heart, Lung, and Blood Institute, National Institute of Mental Health, National Institute on Drug Abuse, National Institute of Environmental Health Sciences, Eunice Kennedy Shriver National Institute of Child Health and Human Development, FP7 Health
Awards: G1075849409, G1093531541, G1099494159, G1108774313, G1110999434, G1133087115, G119964413, Sustainable and integrated production of liquid biofuels, bioenergy and green chemicals from glycerol in biorefineries, G1311351439, G1393617006, G1409398652, G1420010978, G1436318246, The Effects of Estradiol on Genetic Risk for Disordered Eating During Puberty, G1520690021, G1569838456, G1671148033, G1698415274, G178382592, G1795780048, G1863377769, Building a Unique National Community Based Twin Repository, G2055575246, G2189011847, G2238725043, G2241025455, G2330461282, USE &ABUSE OF ALCOHOL--A BEHAVIOR-GENETICS PERSPECTIVE, G2382756871, G242423306, G2433343305, Hormones in Sex-different Developmental Psychopathology, A twin study of ovarian hormones and disordered eating, G2473961061, G2496263360, G2512784349, G2563833389, G2684863890, G2761558319, G279455444, G2798809293, G2861369480, G289688219, G2899750288, G292374140, G2973790809, G3077543175, Australian Centre of Excellence in Twin Research, G3121891270, Oldest-old Mortality - Demographic Models and Analysis, G3127488624, Developmental Change in Temperament in Preschoolers: Implications and Etiology, G31757887, G3207356259, G3250631134, G326470056, G3294462333, G3333874486, Research Training - Genetics of Substance Abuse, The VETSA Longitudinal Twin Study of Cortisol and Aging, G3368366672, G3381003921, Enabling CLimate Information Services for Europe - ECLISE, G3444887196, G357049385, Gene-environment Interactions in Childhood Conduct Problems, G3612415582, G3649217510, G37215126, G3731392153, G3757293254, G3794989908, G387469706, G3879514817, G393177772, G3964375220, G3969217981, G4050873927, Adolescent Alcohol Abuse: A Twin-Study Perspective, G4067196137, Determinants of Behavioral Development, Global Ethics in Science and Technology, G423326604, Center on Antisocial Drug Dependence: The Genetics of HIV Risk Behaviors, G4329622382, G4330096051, G4367295956, G4374445680, G4381011041, International research project on physical growth and long-term prognosis in Twins and multiple births, Biobank Standardisation and Harmonisation for Research Excellence in the European Union, G4446757277, G4536776401, HEALTH AND PSYCHOSOCIAL FACTORS IN OLDER BLACK TWINS, G4599390081, G4682662344, G4701882443, European Network for Genetic and Genomic Epidemiology, G471988321, G4757721458, G4924186877, G519084567, G5349006154, G5418186242, The VETSA Longitudinal MRI Twin Study of Aging, G5455887142, G5468713758, Development of Externalizing Behavior Problems: Gene-Environment Interplay, G5612962370, Integrating contextual, proximal, and individual risks for child conduct problems, G5702163051, G5876242077, BEHAVIORAL PRECURSORS OF ALCOHOLISM--TWIN FAMILY STUDIES, G597584310, G6030094504, DNA methylation differences between identical twins, G6229538190, G626177176, Influências genéticas e de envolvimento na actividade física, aptidão e saúde: o estudo de famílias da Madeira, G6367764764, G6412048503, G6465366315, G6509019740, G6698395689, G6698906416, G6728033037, G6872390368, G7003971911, G70080636, G7031888331, G7123559464, G7245677640, G7365436527, Adolescent Alcohol Abuse: A Twin-Study Perspective, G7583787834, The VETSA Longitudinal Twin Study of Cognition and Aging, G7689853932, G7780068114, G7787549875, Genetic Influences on Activity Level in Early Childhood, G7914056507, G7956052275, G8015511773, The Greatest Generation: The NAS-NRC WWII Twin Registry as a Scientific Resource, Familial Transmission of Eating Pathology &Sex Hormones, G822877548, Longitudinal twin study of work and life environmental factors affecting psychosomatic symptoms of nurses., Predicting birth and early life outcomes, The VETSA Longitudinal Twin Study of Cognition and Aging (VETSA 4), G841499813, G8467350387, G8547141348, G858414785, G8590760118, G8642381730, The VETSA longitudinal twin study of cognition and aging, G8898866349, How do we change from conception to birth?, G9000309104, G961365294, G976534054
OpenAlex ID: W2119826281