Work

Reply to Liu et al.: HNF4A and PTBP1 expression in the brain of neurodegenerative disease patients

Year: 2015

Type: letter

Abstract: We thank Liu et al. (1) for their comments on our manuscript in which hepatocyte nuclear factor 4 alpha (HNF4A) and polypyrimidine tract binding protein 1 (PTBP1) are identified as potential dynamic biomarkers for Parkinson’s disease (PD) (2). In our study, transcriptomic and network-based metaanalysis identified HNF4A and PTBP1 as the most significant up-regulated and down-regulated genes, respectively, in blood of PD. Given the involvement of HNF4A in glucose metabolism and PTBP1 in insulin regulation, our findings provide a molecular rationale for the impaired insulin signaling observed in PD patients.

Source: Proceedings of the National Academy of Sciences

DOI: 10.1073/pnas.1510113112

Authors: Jose A. Santiago, Judith A. Potashkin

Institution: Rosalind Franklin University of Medicine and Science

Language: English

Topic: Alzheimer's disease research and treatments

Subfield: Physiology

Field: Medicine

Domain: Health Sciences

SDG: Good health and well-being

Open Access status: green

Funder: Medical Research and Materiel Command