Work

Chemoenzymatic synthesis of α-dystroglycan core M1 O-mannose glycans

Year: 2015

Type: article

Abstract: The diversity-oriented chemoenzymatic synthesis of α-dystroglycan (α-DG) core M1 O-mannose glycans has been achieved via a three-step sequential one-pot multienzyme (OPME) glycosylation of a chemically prepared disaccharyl serine intermediate. The high flexibility and efficiency of this chemoenzymatic strategy was demonstrated for the synthesis of three more complex core M1 O-mannose glycans for the first time along with three previously reported core M1 structures.

Source: Chemical Communications

DOI: 10.1039/c5cc02913a

Authors: Yan Zhang, Caicai Meng, Lan Jin, Xi Chen, Fengshan Wang, Hongzhi Cao

Institutions: Shandong University, University of California System, University of California, Davis

Language: English

Topic: Carbohydrate Chemistry and Synthesis

Subfield: Organic Chemistry

Field: Chemistry

Domain: Physical Sciences

SDG: Good health and well-being

Open Access status: green

Funders: National Institute for Health and Care Research, National Natural Science Foundation of China, Eunice Kennedy Shriver National Institute of Child Health and Human Development