β-Strand mimics based on tetrahydropyridazinedione (tpd) peptide stitching
Year: 2015
Type: article
Abstract: Short peptides featuring a tetrahydropyridazinedione (tpd) backbone tether exhibit reduced conformational flexibility external to the heterocyclic constraint. Analysis by NMR, molecular modeling and X-ray crystallography suggests both covalent and non-covalent stabilization of extended peptide conformations. An efficient solid-phase protocol was developed for the synthesis of a new class of β-strand mimics based on oligomeric tpd subunits.
Source: Chemical Communications
DOI: 10.1039/c5cc07189e
Authors: Chang Won Kang, Matthew P. Sarnowski, Sujeewa Ranatunga, Lukasz Wojtas, Rainer S. Metcalf, Wayne C. Guida, Juan R. Del Valle
Institution: University of South Florida
Language: English
Subfield: Molecular Biology
Domain: Life Sciences
Open Access status: green
Awards: G4213239949, G895663156, G9000149388
OpenAlex ID: W1763538768