Liver transplantation for hereditary tyrosinemia: the Quebec experience.
Year: 1990
Type: article
Study design: Observational Study
Abstract: Sixteen tyrosinemic patients were evaluated in our institution for a possible liver transplantation. All patients showed biochemical and/or radiological evidence of liver dysfunction. Renal involvement was found to be more abnormal than expected. Seven patients have been transplanted, with two patients receiving a combined liver-kidney transplant. Hepatocarcinoma was detected in two of eight patients in whom the whole liver was examined. Six (37.5%) of the initial 16 patients have died since evaluation, one of the six dying after combined liver-kidney transplantation. Posttransplantation survival was 86%, with normal liver function, normal growth, and no recurrence of neurological crises on a normal diet.
Source: Europe PMC (PubMed Central)
Authors: K Paradis, A Weber, E G Seidman, J Larochelle, L Garel, C Lenaerts, C C Roy
Institution: Centre Hospitalier Universitaire Sainte-Justine
Language: English
Subfield: Clinical Biochemistry
Domain: Life Sciences
Open Access status: green
OpenAlex ID: W176376304