Utilization of Marrow Stromal Cells for Gene Transfer into the CNS
Year: 2003
Type: book-chapter
Abstract: In the past several decades, neurotransplantation has been investigated for the study of development of the normal nervous system and possible functional restoration and repair of diseased and damaged nervous tissue (1,2). In patients with Parkinson’s disease, transplantation of dopamine-producing human and pig fetal tissues has resulted in varying degrees of clinical improvements, which correlated with graft survival and anatomical integration of the grafted fetal cells into the host brain (3–5), albeit, the control of dopamine release remains an issue (5). In animal studies, implantation of neural stem cells and partially differentiated embryonic stem cells into lesioned brain and spinal cord resulted in more rapid behavioral improvement in experimental models of spinal cord injury, stroke, and neurotrauma (6–11). Although implantation of embryonic stem cells can be a promising method of cell therapy, obtaining fetal and embryonic tissues has presented major logistical, ethical, and immunological barriers (12,13). Thus, autologous cells from the bone marrow, marrow stromal cells, can be an attractive alternative source of tissue for grafting and treatment of neurological diseases (11).
Source: Humana Press eBooks
Language: English
Subfield: Genetics
Field: Medicine
Domain: Health Sciences
Open Access status: hybrid
OpenAlex ID: W176563582