Work

Adaptive immune response to therapy in hmgcr autoantibody myopathy

Year: 2015

Type: article

Abstract: INTRODUCTION: We evaluated the response to immunosuppression in a case of 3-hydroxy-3-methylglutaryl-coenzyme A reductase (HMGCR)-autoantibody myopathy. METHODS: T- and B-cell subsets were determined by flow cytometry pre- and posttherapy. RESULTS: Baseline immune profiling demonstrated strikingly elevated T-follicular helper (Tfh) cells and plasmablasts. Immunosuppression resulted in clinical improvement and decreased Tfh cells, plasmablasts, and autoantibodies. CONCLUSIONS: Immune profiling in HMGCR-autoantibody myopathy suggests a B-cell-mediated disease. Tfh cells and plasmablasts may be therapeutic biomarkers.

Source: Muscle & Nerve

DOI: 10.1002/mus.24947

Authors: John S. Yi, Melissa A. Russo, Kent J. Weinhold, Jeffrey T. Guptill

Institutions: Duke University, Duke Medical Center

Language: English

Topic: Inflammatory Myopathies and Dermatomyositis

Subfield: Epidemiology

Field: Medicine

Domain: Health Sciences

SDG: Good health and well-being

Open Access status: green

Funders: Donostia International Physics Center, Center for AIDS Research, Duke University, National Institute of Allergy and Infectious Diseases, National Institute of Neurological Disorders and Stroke