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Structural Basis for Force Decline in Edl-muscle From Mdx Mice After Eccentric Contraction

Year: 1993

Type: conference-paper

Abstract: EDL-muscles from mdx mice display an irreversible decline in maximal isometric force after eccentric contractions (Moens et al., J MRCM, 14, 446-51). About 50% of the force decline could be explained by membrane-damaged fibres. The unexplained part of the force decline could be caused by damage at the myotendinous junction (MTJ). Ultrathin longitudinal sections were cut at 100 µm intervals from blocks that contained both tendon and muscle. No fibres display separation of basement- and plasma membrane at the MTJ. Our results indicate yet another cause for the unexplained part of the force decline observed after eccentric contractions in EDL muscles from mdx mice.

Source: Digital Access to Libraries (Université catholique de Louvain (UCL), l'Université de Namur (UNamur) and the Université Saint-Louis (USL-B))

Authors: Phww. Baatsen, Pierre Moens, Georges Maréchal

Language: English

Topic: Muscle Physiology and Disorders

Subfield: Molecular Biology

Field: Biochemistry, Genetics and Molecular Biology

Domain: Life Sciences

SDG: Good health and well-being

Open Access status: green

OpenAlex ID: W1768882546

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