Work

Epigenetic and microRNA regulation during osteoarthritis development

Year: 2015

Type: article

Abstract: Osteoarthritis (OA) is a common degenerative joint disease, the pathological mechanism of which is currently unknown. Genetic alteration is one of the key contributing factors for OA pathology. Recent evidence suggests that epigenetic and microRNA regulation of critical genes may contribute to OA development. In this article, we review the epigenetic and microRNA regulations of genes related to OA development. Potential therapeutic strategies may be developed on the basis of novel findings.

Source: F1000Research

DOI: 10.12688/f1000research.6548.1

Authors: Di Chen, Jie Shen, Tianqian Hui

Institutions: Rush University Medical Center, Washington University in St. Louis

Language: English

Topic: Osteoarthritis Treatment and Mechanisms

Subfield: Rheumatology

Field: Medicine

Domain: Health Sciences

SDG: Good health and well-being

Open Access status: gold

Estimated APC paid: $1,350