Effects of Neonatal FGF2 Administration on Vocalizations in Rats Susceptible to Anxiety and Depression
Year: 2012
Type: dissertation
Abstract: In this study we examined whether an early life intervention can permanently alter individual differences in emotional behavior, as modeled using bred high and low responder rats.We found that neonatal FGF2 administration permanently alters the emotional brain systems of individuals prone to anxious and inhibited behavior (bred low responders) as well as those animals that do not show these vulnerabilities (bred high responders).These neural changes increased positive ultrasonic vocalizations in response to experimenter induced play.The brain and behavior altering changes that result from a single neonatal dose of FGF2 could be a powerful treatment for individuals vulnerable to depression and anxiety-like behavior.
Author: Rikav Chauhan
Language: English
Subfield: Cellular and Molecular Neuroscience
Field: Neuroscience
Domain: Life Sciences
Open Access status: green
OpenAlex ID: W177381170