Work

In Situ Protein-DNA Interactions AT A Dioxin-Responsive Enhancer Associated with the Cytochrome P1-450 Gene

Year: 1987

Type: article

Abstract: We used an in situ exonuclease III protection technique (C. Wu, Nature [London] 309:229, 1984) to analyze protein-DNA interactions at a dioxin-responsive enhancer. Our results imply that the 2,3,7,8-tetrachlorodibenzo-p-dioxin-receptor complex interacts with the dioxin-responsive enhancer to activate transcription of the cytochrome P1-450 gene.

Source: Molecular and Cellular Biology

DOI: 10.1128/mcb.7.8.3008

Authors: L K Durrin, J P Whitlock

Institutions: Stanford Medicine, Stanford University

Language: English

Topic: Toxic Organic Pollutants Impact

Subfield: Health, Toxicology and Mutagenesis

Field: Environmental Science

Domain: Physical Sciences

Open Access status: green

Funders: National Institutes of Health, National Cancer Institute, National Institute of Environmental Health Sciences

Awards: G2033354203, G2960599440