Combined Modality Strategies in the Treatment of Head and Neck Cancer
Year: 2003
Type: book-chapter
Abstract: Head and neck cancer (HNC) comprises 5–6% of all malignancies (1). Approximately 650,000 cases will be diagnosed worldwide in 2000 (2). The American Cancer Society estimates that in the United States alone approx 40,300 new cases of HNC will be diagnosed annually with approx 11,700 deaths associated from this disease (1). If cured, HNC patients are at increased risk of developing a second malignancy, estimated to occur at an annual incidence of 3–7% (3). Field carcinogenesis, as initially proposed by Slaughter et al. in 1953, describes the concept of repetitive carcinogen exposure affecting the entire aerodigestive tract, resulting in cumulative toxicity to a large mucosal surface (4). S qua-mous cell carcinomas constitute >90% of the histology of head and neck carcinomas. Therefore, this chapter will focus solely on this histology type unless specified otherwise.
Source: Humana Press eBooks
Authors: Cathy Eng, Everett E. Vokes
Language: English
Topic: Head and Neck Cancer Studies
Subfield: Otorhinolaryngology
Field: Medicine
Domain: Health Sciences
Open Access status: hybrid
OpenAlex ID: W177455951