Work

New ribosomes for new memories?

Year: 2015

Type: article

Abstract: Widely thought to be a housekeeping process, the regulation and synthesis of rRNA emerges as a potentially central mechanism for the maintenance of synaptic plasticity and memory. We have recently shown that an essential component of late-phase synaptic plasticity is rRNA biosynthesis - the rate-limiting step in the production of new ribosomes. We hypothesize that a particular population of ribosomes is generated upon learning-associated neural activity to alter the rate of synthesis of plasticity factors at tagged synapses that will support the maintenance of synaptic plasticity and memory.

Source: Communicative & Integrative Biology

DOI: 10.1080/19420889.2015.1017163

Authors: A Iván Hernández, Juan M Alarcon, Kim D Allen

Institutions: State University of New York, SUNY Downstate Health Sciences University

Language: English

Topic: Neuroscience and Neuropharmacology Research

Subfield: Cellular and Molecular Neuroscience

Field: Neuroscience

Domain: Life Sciences

Open Access status: gold

Estimated APC paid: $1,459

Funder: National Institute of Neurological Disorders and Stroke