Response to Letters Regarding Article, “Dietary Linoleic Acid and Risk of Coronary Heart Disease: A Systematic Review and Meta-Analysis of Prospective Cohort Studies”
Year: 2015
Type: review
Abstract: We appreciate Lucas' and Hoenselaar's comments on our metaanalysis of linoleic acid (LA) and coronary heart disease (CHD) events. Despite theoretical concern about the potential proinflammatory and thrombogenic properties of omega-6 polyunsaturated fats, evidence from human studies to support a positive association between intakes of these fatty acids and biomarkers of inflammation or risk of cardiovascular disease or cancer is limited. On the contrary, epidemiological studies and randomized, clinical trials have documented beneficial effects of replacing saturated fat with omega-6 polyunsaturated fats on blood lipids and cardiovascular disease risk. We agree with Lucas that the ratio of omega-6 to omega-3 is not particularly meaningful because both types of fatty acids are essential and confer health benefits and there is little evidence that the ratio per se is related to health outcomes.
Source: Circulation
Language: English
Subfield: Nutrition and Dietetics
Field: Nursing
Domain: Health Sciences
Open Access status: bronze
OpenAlex ID: W1780044989