Work

Decreased Interferon Alpha/Beta Signature Associated with Human Lung Tumorigenesis

Year: 2015

Type: article

Abstract: Accumulating evidence suggests that interferon (IFN) alpha/beta are involved in antitumor immunity and cancer immunoediting, but information on the antitumor effects of IFN alpha/beta in lung cancer is limited. In our study, we elucidated the IFN alpha/beta signature during both human fetal lung development and lung tumorigenesis. Our findings indicated gradual upregulation in the IFN alpha/beta signature during human fetal lung development. In addition, this signature was progressively downregulated in normal human airway epithelial cells from lung cancer patients, in immortalized human bronchial epithelial cell lines from later passages, in late-stage lung squamous cell carcinoma (LSCC) tissues, and in LSCC tissues exhibiting lymph node metastasis. Therefore, from its earliest stages, lung tumorigenesis may be associated with a decreased IFN alpha/beta signature. This association may provide insight to guide the detection of high-risk lung cancer patients.

Source: Journal of Interferon & Cytokine Research

DOI: 10.1089/jir.2015.0061

Authors: Run Tong, Lin Feng, Lei Zhang, Jianzhi Zhang, Yousheng Mao, Kaitai Zhang, Yanning Gao, Guiqi Wang, Shujun Cheng

Institutions: Chinese Academy of Medical Sciences & Peking Union Medical College, State Key Laboratory of Molecular Oncology, Cancer Hospital of Chinese Academy of Medical Sciences, Peking University, Peking University Cancer Hospital

Language: English

Topic: interferon and immune responses

Subfield: Immunology

Field: Immunology and Microbiology

Domain: Life Sciences

SDG: Good health and well-being

Open Access status: green

OpenAlex ID: W1783330161

FWCI: 0.138

Cites: 31

Cited by: 14

Related to: 10