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Cytotoxic Effect of Luteolin on Human Colorectal Cancer Cell Line (HCT-15): Crucial Involvement of Reactive Oxygen Species

Year: 2013

Type: article

Abstract: Background: Colorectal cancer, a major health concern worldwide, is the third mostcommon form of cancer and second leading cause of cancer-related deaths. Theflavonoids are naturally occurring diphenylpropanoids ubiquitous in plant foods andimportant components of the human diet. Luteolin, a bioflavonoid, possesses manybeneficial effects including antioxidant, anti-inflammatory, anti-allergic activities. Methods:We used the HCT-15 colon adenocarcinoma cell line in this study. Cellswere treated with luteolin (100 µM). Results: Membrane damage markers such as alkaline phosphatase and lactatedehydrogenase were analyzed in a time-dependent manner. Luteolin increased reactiveoxygen species in a time-dependent manner. DNA damage, a hallmark of apoptosis,was induced by luteolin as analyzed by agarose gel electrophoresis. Conclusion: Luteolin acts as a potential cytotoxic agent that can be used to treatcolorectal cancer.

Source: DOAJ (DOAJ: Directory of Open Access Journals)

Authors: Ashok Kumar Pandurangan, Sudhandiran Ganapasam

Institution: University of Madras

Language: English

Topic: Flavonoids in Medical Research

Subfield: Pharmacology (medical)

Field: Medicine

Domain: Health Sciences

SDG: Good health and well-being

Open Access status: diamond

OpenAlex ID: W1784546543

FWCI: 0.215

Cites: 26

Cited by: 6

Related to: 10