Work

Chromosome-Mediated Transfer of the Murine Na,K-ATPase Alpha Subunit Confers Ouabain Resistance

Year: 1987

Type: article

Abstract: We transferred murine NIH 3T3 metaphase chromosomes into monkey CV-1 cells to investigate the different ouabain sensitivities of rodent and primate cells. In 16 ouabain-resistant transferents, the mouse Na,K-ATPase alpha 1 subunit gene was detected, suggesting that structural differences between the rodent and primate alpha 1 subunits determine the different ouabain sensitivities.

Source: Molecular and Cellular Biology

DOI: 10.1128/mcb.7.8.2985

Authors: D Fallows, R B Kent, D L Nelson, J R Emanuel, R Levenson, D E Housman

Institution: Massachusetts Institute of Technology

Language: English

Topic: Ion Transport and Channel Regulation

Subfield: Molecular Biology

Field: Biochemistry, Genetics and Molecular Biology

Domain: Life Sciences

Open Access status: green

Funders: March of Dimes Foundation, American Heart Association, National Cancer Institute

Awards: G7355644372, G868882532