Serum 25-Hydroxyvitamin D Levels Are not Associated with Adverse Outcomes in Clostridium Difficile Infection
Year: 2015
Type: article
Study design: Observational Study
Abstract: Clostridium difficile infection (CDI) is a significant source of healthcare-associated morbidity and mortality. This study investigated whether serum 25-hydroxyvitamin D is associated with adverse outcomes from CDI. Patients with CDI were prospectively enrolled. Charts were reviewed and serum 25-hydroxyvitamin D was measured. The primary outcome was a composite definition of severe disease: fever (temperature >38°C), acute organ dysfunction, or serum white blood cell count >15,000 cells/µL within 24-48 hours of diagnosis; lack of response to therapy by day 5; and intensive care unit admission; colectomy; or death within 30 days. Sixty-seven patients were included in the final analysis. Mean (±SD) serum 25-hydroxyvitamin D was 26.1 (±18.54) ng/mL. Severe disease, which occurred in 26 (39%) participants, was not associated with serum 25-hydroxyvitamin D [odds ratio (OR) 1.00; 95% confidence interval (CI) 0.96-1.04]. In the adjusted model for severe disease only serum albumin (OR 0.12; 95%CI 0.02-0.64) and diagnosis by detection of stool toxin (OR 5.87; 95%CI 1.09-31.7) remained independent predictors. We conclude that serum 25-hydroxyvitamin D is not associated with the development of severe disease in patients with CDI.
Source: Infectious Disease Reports
Institutions: University of Chicago, University of Michigan, Michigan Medicine
Language: English
Subfield: Infectious Diseases
Field: Medicine
Domain: Health Sciences
Open Access status: gold
Estimated APC paid: $2,172
Funders: University of Michigan, National Institutes of Health, Michigan Institute for Clinical and Health Research, National Institute on Aging, National Institute of Allergy and Infectious Diseases, National Institute of Diabetes and Digestive and Kidney Diseases, National Center for Advancing Translational Sciences
Awards: G1341773926, G1762620404, G1815451664, Clostridium difficile Cooperative Research Center, G2507028199, G28982667, G3223614423, Digestive Health and Diseases (DHD) Training Grant, Host and Microbial Biomarkers Related to the Development of Complicated Clostridium difficile Infection, G898378059, G9000012814, G9000087953, G9000221581, Center for Interdisciplinary Study of Inflammatory Intestinal DIsorders (C-IID), Claude D. Pepper Older Americans Independence Center at the University of Michigan (UM Pepper Center)
OpenAlex ID: W1785772156