Dehydroepiandrosterone (DHEA) replacement decreases insulin resistance and lowers inflammatory cytokines in aging humans
Year: 2011
Type: article
Study designs: Randomized Controlled Trial, Clinical Trial
Abstract: Plasma dehydroepiandrosterone (DHEA) decreases ~80% between ages 25 and 75 yr. In a preliminary study, we found that 6 mo of DHEA replacement improved insulin action in elderly individuals. The purpose of the present larger, randomized double-blind study was to determine whether a longer period of DHEA replacement improves glucose tolerance. Fifty-seven men and 68 women aged 65 to 75 yr were randomly assigned to 50 mg DHEA or placebo once daily. Year one was a randomized, double blind trial. Year 2 was an open label continuation. DHEA replacement improved glucose tolerance in participants who had abnormal GT initially, reduced plasma triglycerides, and the inflammatory cytokines IL6 and TNFα.
Source: Aging
Language: English
Subfield: Endocrinology, Diabetes and Metabolism
Field: Medicine
Domain: Health Sciences
Open Access status: hybrid
Awards: G1182707082, G1329088937, G507895129, Caloric restriction, exercise, and glucoregulation in humans, Washington University Institute of Clinical and Translational Sciences, Washington University Institute of Clinical and Translational Sciences (UL1), Is DHEA Replacement Therapy Beneficial?, EXERCISE AS PREVENTIVE MEDICINE IN THE AGING PROCESS, G889535532, G9000042762, G9000173792, Washington University Nutrition Obesity Research Center, GENERAL CLINICAL RESEARCH CENTER
OpenAlex ID: W178868123