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Adult acute lymphoblastic leukemia

Year: 2010
Type: review
Abstract: Acute lymphoblastic leukemia (ALL), a clonal expansion of hematopoietic blasts, is a highly heterogeneous disease comprising many entities for which distinct treatment strategies are pursued. Although ALL is a success story in pediatric oncology, results in adults lag behind those in children. An expansion of new drugs, more reliable immunologic and molecular techniques for the assessment of minimal residual disease, and efforts at more precise risk stratification are generating new aspects of adult ALL therapy. For this review, the authors summarized pertinent and recent literature on ALL biology and therapy, and they discuss current strategies and potential implications of novel approaches to the management of adult ALL. Cancer 2010. (c) 2010 American Cancer Society.
Source: Cancer
DOI: 10.1002/cncr.24862
Authors: Stefan Faderl, Susan O'Brien, Ching‐Hon Pui, Wendy Stock, Meir Wetzler, Dieter Hoelzer, Hagop M. Kantarjian
Institutions: The University of Texas MD Anderson Cancer Center, St. Jude Children's Research Hospital, University of Tennessee Health Science Center, University of Chicago, Roswell Park Comprehensive Cancer Center, University Hospital Frankfurt
Language: English
Field: Medicine
Open Access status: green
OpenAlex ID: W1789507134
FWCI: 3.762
Cites: 133
Cited by: 288
Related to: 10