Year: 2012
Type: dissertation
Abstract: Randomized controlled trials in traumatic brain injury (TBI) are challenging due to the inherent heterogeneity of the patient population, the lack of early mechanistic end points, and relative insensitivity of outcome measures. Approaches to deal with the heterogeneity of the patient population are presented in this thesis. The use of strict enrollment criteria is not recommended, as this is inefficient. Rather, broad enrollment criteria may be preferred combined with covariate adjustment in the analysis phase. Dichotomization of the Glasgow Outcome Scale as the primary outcome measure in most trials is not recommended. Ordinal approaches to analysis of tre
Author: Bob Roozenbeek
Language: English
Subfield: Statistics and Probability
Field: Mathematics
Domain: Physical Sciences
Open Access status: green
OpenAlex ID: W1789821562