Vascular Remodeling: Just Say NO!
Year: 2011
Type: dissertation
Abstract: \\xe2\\x80\\x9cYou are only as old as your endothelium\\xe2\\x80\\x9d, as often stated by Paul M Vanhoutte, when\\nopening his famous \\xe2\\x80\\x9cMechanisms of Vasodilation\\xe2\\x80\\x9d meetings from 1980 onwards, highlights\\nthe importance of endothelium and the continuous process of vascular remodeling\\nin many physiological and pathophysiological situations as embryogenesis, wound healing,\\ntumor growth and ischemic disease. In chronic and acute cardiovascular occlusive\\ndisease, different types of vascular remodeling contribute to tissue repair and vascular\\ngrowth. Firstly, collateral growth represents the expansive growth of preexisting vessels,\\nforming collateral bridges between arterial networks. Secondly, neovascularization refers\\nto vascular growth from a combination of three different mechanisms: vasculogenesis\\nis the formation of blood vessels by endothelial progenitors while angiogenesis refers\\nto capillary sprouting or intussusceptive growth and arteriogenesis to the subsequent\\nstabilization of these new vascular structures by mural cells1. Distinct, but partially overlapping,\\ncellular and molecular pathways drive collateral growth and neovascularization\\n(Figure 1)2. Hypoxia is known to stimulate neovascularization in the setting of ischemia,\\nwhereas fluid shear stress (FSS) might be the most important trigger for initiation of\\ncollateral growth. Besides these specific initial triggers, all types of vascular remodeling\\nshare growth factors, chemokines, proteases, and inflammatory cells, which play different\\nroles in promoting and refining these processes.
Author: Barend Mees
Language: English
Subfield: Molecular Biology
Domain: Life Sciences
Open Access status: green
OpenAlex ID: W1791638111