Optimizing Treatment Strategies Using Nucleos(t)ide Analogues for Patients with Chronic Hepatitis B
Year: 2010
Type: dissertation
Abstract: Hepatitis B infection has a complex natural history and causes a wide spectrum of\\ndisease. Although effective vaccines are available, universal vaccination has yet not\\nbeen reached. Currently, an estimated 350 million people are chronically infected, and\\n0.5-1.2 million subjects die every year due to long-term sequalae of hepatitis B related\\nchronic liver disease, such as liver cirrhosis and hepatocellular carcinoma Despite\\nevidence-based treatment guidelines areas of disagreement on the management of\\nchronic hepatitis B virus (HBV) infection still exist.\\nWith the currently approved treatment options the ultimate goal is to prevent the\\ndevelopment of long-term sequelae of chronic liver disease. Current treatment strategies\\nconsist of either therapies with fi nite duration that aims to achieve sustained\\noff-treatment remission (interferon-based therapy), or long-term therapy that aims to\\nmaintain on-treatment response (nucleos(t)ide analogues).
Author: Jurriën G.P. Reijnders
Language: English
Topic: Hepatitis B Virus Studies
Subfield: Epidemiology
Field: Medicine
Domain: Health Sciences
Open Access status: green
OpenAlex ID: W1791779491