Three genes for enzymes of the pyruvate dehydrogenase complex map to human chromosomes 3, 7, and X.
Year: 1990
Type: article
Abstract: The genes for three proteins of the pyruvate dehydrogenase (PDH) complex have been assigned to human chromosomes by Southern analysis of a panel of human-rodent somatic cell hybrid DNAs with cDNA probes for these genes. PDH-E1 alpha has been localized on human chromosome 3p13-q23. The assignments of lipoamide dehydrogenase(E3) and PDH-E1 alpha [corrected] to chromosomes 7 and Xp, respectively, have been confirmed. Restrictive-fragment-length polymorphisms have been identified with E3, which will permit further localization of this gene by genetic linkage analysis.
Source: Europe PMC (PubMed Central)
Authors: S Olson, B J Song, T L Huh, Y T Chi, R L Veech, O W McBride
Institution: National Institutes of Health
Language: English
Subfield: Biochemistry
Domain: Life Sciences
Open Access status: green
OpenAlex ID: W179240516