Year: 2015
Type: article
Abstract: Hedyotis corymbosa, with local name rumput mutiara, is an anti-inflammatory, anti-cancer and hepatoprotective traditional medicine. The ethanol extract of H. corymbosa L. shows inhibitory activity to human YMB-1 breast cancer cell line with an IC50 of 6.51 mg/ml. The methylene chloride fraction shows a potential cytotoxic activity with an IC50 of 2.75 mg/ml. To obtain a lead compound, the extract was further purified by column chromatography. A pure compound is obtained which shows inhibitory activities against YMB-1, HL60 and KB human cell lines with IC50 values of 0.7; 11.0 and 104.2 mg/ml, respectively. Based on the 1D and 2D FT-NMR data, the isolated compound is an asperuloside.
Source: Journal of Tropical Life Science
Institutions: Indonesian Institute of Sciences, Osaka City University
Language: English
Subfield: Organic Chemistry
Field: Chemistry
Domain: Physical Sciences
Open Access status: gold
Estimated APC paid: $196
OpenAlex ID: W1793230130