Work

Two Faces of SIVA

Year: 2015

Type: article

Abstract: Summary: In non–small cell lung cancer cells that contain a mutated KRAS gene, SIVA, a p53 target gene that is critical for apoptosis, is overexpressed in a p53-independent manner and promotes tumorigenesis through the stimulation of mTOR signaling. The ablation of Siva in conditional knockout mice results in an inhibition of tumor development that makes SIVA an interesting new candidate therapeutic target for the treatment of a carcinoma with few therapeutic options. Cancer Discov; 5(6); 581–3. ©2015 AACR. See related article by Van Nostrand and colleagues, p. 622.

Source: Cancer Discovery

DOI: 10.1158/2159-8290.cd-15-0484

Authors: Lois Resnick-Silverman, James J. Manfredi

Institution: Icahn School of Medicine at Mount Sinai

Language: English

Topic: Cancer-related Molecular Pathways

Subfield: Oncology

Field: Medicine

Domain: Health Sciences

SDG: Good health and well-being

Open Access status: green

Funder: National Cancer Institute