Work

Biocompatible d -penicillamine conjugated Au nanoparticles: targeting intracellular free copper ions for detoxification

Year: 2015

Type: article

Abstract: High thiophillicicity of the Au-nanoparticle (Au NP) surface leads to covalent attachment of D-penicillamine molecules to Au NPs to form biocompatible D-penicillamine conjugated Au NPs. The latter are highly water-dispersible, exhibit no cytotoxicity, and can readily penetrate the cell membrane to target intracellular free copper ions for selective copper detoxification in the presence of the other divalent essential metal ions including Zn(II), Fe(II), Mn(II), Ca(II), and Mg(II), thus opening up a new avenue for improving the efficacy and pharmacokinetics of D-penicillamine, an important clinical drug currently used to treat the copper overload-related diseases and disorders.

Source: Journal of Materials Chemistry B

DOI: 10.1039/c5tb00189g

Authors: Murthi S. Kandanapitiye, Chamila Gunathilake, Mietek Jaroniec, Songping D. Huang

Institution: Kent State University

Language: English

Topic: Gold and Silver Nanoparticles Synthesis and Applications

Subfield: Electronic, Optical and Magnetic Materials

Field: Materials Science

Domain: Physical Sciences

SDG: Good health and well-being

Open Access status: green

Funders: National Institutes of Health, National Cancer Institute