Year: 2011
Type: review
Abstract: Homeostatic processes that regulate electrical activity in neurones are now an established aspect of physiology and rest on a large body of experimental evidence that points to roles in development, learning and memory, and disease. However, the concepts underlying homeostasis are too often summarized in ways that restrict their explanatory power and obviate important subtleties. Here, we present a review of the underlying theory of homeostasis--control theory--in an attempt to reconcile some existing conceptual problems in the context of neuronal physiology. In addition to clarifying the underlying theory, this review highlights the remaining challenges posed when analysing homeostatic phenomena that underlie the regulation of neuronal excitability. Moreover, we suggest approaches for future experimental and computational work that will further our understanding of neuronal homeostasis and the fundamental neurophysiological functions it serves.
Source: The Journal of Physiology
Authors: Timothy O’Leary, David J. A. Wyllie
Institution: University of Edinburgh
Language: English
Subfield: Cellular and Molecular Neuroscience
Field: Neuroscience
Domain: Life Sciences
Open Access status: bronze
OpenAlex ID: W1800303662