Year: 2014
Type: article
Study design: Observational Study
Abstract: OBJECTIVES: To determine whether α-synuclein dinucleotide repeat (REP1) genotypes are associated with survival in Parkinson's disease (PD). METHODS: Investigators from the Genetic Epidemiology of Parkinson's Disease Consortium provided REP1 genotypes and baseline and follow-up clinical data for cases. The primary outcome was time to death. Cox proportional hazards regression models were used to assess the association of REP1 genotypes with survival. RESULTS: Twenty-one sites contributed data for 6,154 cases. There was no significant association between α-synuclein REP1 genotypes and survival in PD. However, there was a significant association between REP1 genotypes and age at onset of PD (hazard ratio: 1.06; 95% confidence interval: 1.01-1.10; P value = 0.01). CONCLUSIONS: In our large consortium study, α-synuclein REP1 genotypes were not associated with survival in PD. Further studies of α-synuclein's role in disease progression and long-term outcomes are needed.
Source: Movement Disorders
DOI: 10.1002/mds.25841
Authors: Sun Ju Chung, Joanna M. Biernacka, Sebastian M. Armasu, Kari Anderson, Roberta Frigerio, Jan O. Aasly, Grazia Annesi, Anna Rita Bentivoglio, Laura Brighina, Marie‐Christine Chartier‐Harlin, Stefano Goldwurm, Georgios Hadjigeorgiou, Barbara Jasinska‐Myga, Beom Seok Jeon, Yun Joong Kim, Rejko Krüger, Suzanne Lesage, Katerina Markopoulou, George Mellick, Karen E. Morrison, Andreas Puschmann, Eng‐King Tan, David Crosiers, Jessie Theuns, Christine Van Broeckhoven, Karin Wirdefeldt, Zbigniew K. Wszolek, Alexis Elbaz, Demetrius M. Maraganore
Institutions: Asan Medical Center, University of Ulsan, Mayo Clinic, Endeavor Health, St Olav's University Hospital, Institute of Neurological Sciences, National Research Council, Università Cattolica del Sacro Cuore, Azienda Ospedaliera San Gerardo, Inserm, Université Lille Nord de France, Istituti Clinici di Perfezionamento, University of Thessaly, Medical University of Silesia, Mayo Clinic in Florida, Seoul National University Hospital, Hallym University, Hertie Institute for Clinical Brain Research, Centre National de la Recherche Scientifique, Institut du Cerveau, Université Pierre-et-Marie-Curie, Griffith University, University of Birmingham, Lund University, Singapore General Hospital, National Neuroscience Institute, University of Antwerp, Antwerp University Hospital, VIB-UAntwerp Center for Molecular Neurology, Institute Born-Bunge, Karolinska Institutet, Université de Versailles Saint-Quentin-en-Yvelines, Centre de recherche en Epidémiologie et Santé des Populations
Language: English
Subfield: Clinical Neurology
Field: Medicine
Domain: Health Sciences
Open Access status: bronze
Funders: Queen Elizabeth Hospital Birmingham Charity, Belgian Federal Science Policy Office, Fonds Wetenschappelijk Onderzoek, Universiteit Antwerpen, Vlaamse regering, National Institutes of Health, Parkinsonfonden, Medical Research Council, Bijzonder Onderzoeksfonds UGent, National Institute of Neurological Disorders and Stroke, National Institute of Environmental Health Sciences
OpenAlex ID: W1803709850